Published: Oct 8, 2007
Mutant Protein May Cause ALS Disease
by Staff

British researchers have found an altered form of a common protein might be responsible for amyotrophic lateral sclerosis, or ALS disease.


Vasanta Subramanian and colleagues from the University of Bath identified the protein as angiogenin, which is needed for the growth of blood vessels. But they discovered mutant forms of the protein are toxic to the motor neurons that initiate and control muscle contractions.


The researchers believe the gradual accumulation of the mutant proteins might explain the late onset and gradual deterioration of function caused by ALS, eventually leading to death. Subramanian said targeting the altered form of angiogenin might make it possible to prevent the degeneration of motor neurons, thereby halting the progression of the disease.


Famous people who have succumbed to the disease include actor David Niven, and baseball player Lou Gehrig.


The findings appear in the journal Human Molecular Genetics. (c) UPI
Most Recent Published Articles

© Copyright 2004-2012 by Post Chronicle Corp.
Top of Page is best viewed with an 1024x768 screen resolution

tumblr stats

Disclaimer: The views expressed on this site are that of the authors and not necessarily that of The Post Chronicle™. Since we offer our product free of charge, we run banner advertising in order to cover the operating costs of delivering the material. Read More Here  DMCA Policy Here  Privacy Policy Here